E

. [1]
A. K[1]
. P[2]
I. K[1]
M. M[2]
1B' M K A
2' M K A
K: 21/01/02
E: 28/01/02


H , PCOS . M 49 , 16 34 , . T : ) PCOS BMI BMI, ) PCOS BMI BMI, ) BMI, , ) SHBG . T PCOS .
: , PCOS, , , SHBG, BMI.

EIAH
H , 1995, .(1,2) H 167 ,(3) 16 kDa(4,5) . H , , .(6)
E .(7) O . T (PCOS) .(8-10) H PCOS. E, PCOS LH .(8-11) , - - .
O . A PCOS (BMI).(12-16) E, PCOS BMI, .(17,18) O , , .
E , PCOS, , . PCOS .

YIKO KAI MEOO
M 49 , 16 34 , I O ' M K A... K , - - .
O 49 : ) ( I) 19 , 20 29 ( SD 24,03,6 ), PCOS, BMI 19,1 24,9 (21,51,5), ) ( II) 10 , 16 30 (24,73,9 ), PCOS, BMI 25,3 39,5 (31,64,4), ) ( III) 15 , 18 34 (21,93,7 ), BMI 20,3 24,8 (22,01,5), ) ( IV) 5 , 20 32 (23,45,3 ), BMI 25,4 36,2 (28,74,4).
T PCOS, : 1) , 2) >10cm3 10 , 2-8mm, , 3) , , 4) BMI >25kg/m2, 5) , 6) LH/FSH >2,5. E, .
A , (FSH, LH), (PRL), (T, 4A, DHEA-S), 17- (17-OHP), (SHBG) , I II , 3 7 ( ) . E, III IV 3 7 . -20C . O . H IRMA (Human Leptin: Diagnostic Systems Laboratories, Inc., Corporate Headquarters, 445 Medical Center Blvd., Texas, USA), FSH, LH, PRL, , , 17-OHP SHBG (FSH: Radioisotopic Kit, Nichols Institute Diagnostics, San Juan Capistrano, California, 92675, USA. LH: Radioisotopic Kit, Nichols Institute Diagnostics, San Juan Capistrano, California, 92675, USA PRL: Radioisotopic Kit, Nichols Institute Diagnostics, San Juan Capistrano, California, 92675, USA. T: Direct Radio-immunoassay Kit, Sorin, Biomedica. 4A: Gamma Coat [125I] Radio-immunoassay Kit, Incstar Corporation. DHEA-S: Direct Radio-immunoassay Solid Phase Coated Tubes, Zer Science Based Industries Ltd. 17-OHP: ImmuChem Double Antibody [125I] Radio-immunoassay Kit, ICN Pharmaceuticals, Inc. SHBG: ([125]I) Immunoradiometric Assay Kit, Orion Diagnostica).
H unpaired t-test, Pearson.

AOTEEMATA
O , , BMI 1. . E, BMI I III II IV.
2 , (FSH, LH), (PRL), (T, 4A, DHEA-S), 17- (17-OHP), (SHBG) I II. O PCOS ( I II) ( III IV), PCOS .
O , , BMI ( III) PCOS BMI ( I) (p<0,03994). A, PCOS BMI ( II) BMI ( IV) (p<0,03236). PCOS BMI ( II) , >40ng/ml, BMI ( IV), 31,1ng/ml. I II. E, DHEA-S, 17-OHP SHBG , SHBG II I. A, II (p<0,03457), I (p<0,03906). T, II (p<0,0000001).
Y , , BMI , (r=+0,8252, p<0,0001), PCOS (r=+0,8870, p<0,0001) (r=+0,5679, p<0,009). E, (r=+0,6178, p<0,024) (r=+0,9367, p<0,0001) SHBG (r=-0,6326, p<0,020). A, FSH, LH, PRL .



YZHTHH
, , PCOS ( I) ( III). T BMI I III, BMI .
E BMI.(2,4,5,13,14,19-23) H , BMI , (r=+0,8252, p<0,0001), PCOS (r=+0,8870, p<0,0001) (r=+0,5679, p<0,009). O I III I. , . O .(24) T , .(20,24,25) H , , , (r=+0,6178, p<0,024).
A , , PCOS ( II) ( IV). 40% PCOS >40ng/ml, BMI ( IV), 31,1ng/ml. T , PCOS (30%) BMI.(18,26) Y, , PCOS . A PCOS BMI.(12-16)
H (r=+0,9367, p<0,0001) . O .(20) H , , , .(25,27-30) E, BMI .(14)
H , , SHBG (r=-0,6326, p<0,020) (r=+0,9367, p<0,0001), (r=+0,6178, p<0,024). H (12) SHBG.(31) K , .
T, FSH, LH, , , DHEA-S 17-OHP , .(14)

Summary
Panidis D1, Kourtis A1, Roussos D2, Kalahanis J1, Mamopoulos M2.
Serum leptin levels in lean and obese women with PCOS.
Hellen Obstet Gynecol 14(3):223-228, 2002
Correspondence: D. Panidis
119 Mitropoleos str, 54622 Thessaloniki
Tel: 0310992915, 0310230333
This study was designed since the literature data, as far as serum leptin levels in patients with PCOS are concerned, are contradictory and limited in number. We studied 49 women, aged 16-34 years, which were divided in four groups according to the diagnosis of PCOS and BMI values. Our results showed that: a) patients with PCOS and normal BMI presented significantly lower serum leptin levels than those of women with normal BMI, b) patients with PCOS and abnormal BMI had significantly higher serum leptin levels than those of controls with abnormal BMI, c) there was high positive correlation between BMI values, insulin and testosterone levels on the one hand and leptin concentrations on the other, and d) there was high negative correlation between SHBG levels and leptin concentrations. Our results support the view that, in a subgroup of obese patients with PCOS, leptin probably interferes in the pathogenesis of this syndrome.
Key words: Leptin, PCOS, insulin, testosterone, SHBG, BMI.
1B' Department of Obstetrics Gynecology, Aristotle University of Thessaloniki
2C' Department of Obstetrics Gynecology, Aristotle University of Thessaloniki

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A: .
M 119
54622
T: 0310992915 (), 0310230333 ()

 

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