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Summary

Danihel L.
Gestational Trophoblastic Disease
Hellen Obstet Gynecol 14(3): 292-295, 2002

Trophoblast is a unique tissue with a wide range of metabolic, endocrine and angiogenic functions. It is comprised of three types of cells, Cytotrophoblast (CT) or Langhans cells, Syncytiotrophoblast (ST) and Intermediate trophoblastic (IT) cells and invades the endometrium and the myometrium in order to achieve a successful implantation and nourishment of the foetus. This process of invasion seems to be regulated mainly via the mechanism of apoptosis, which, in its turn, is controlled by the bcl-2 protein family that includes the antiapoptotic bcl-2 protein and the proapoptotic bax protein. The trophoblastic cells bare immunohisto-chemical characteristics of epithelial cells and produce hCG and hPL, in variable amounts, depending on the age of pregnancy. The expressions of these proteins, in cases of gestational trophoblastic disease, together with DNA analysis are very helpful tools regarding the characteri-zation of each tumour. Choriocarcinoma is considered a tumour that is curable in most of the cases with an excellent prognosis regarding future fertility. Placental site trophoblastic tumour derives from mature trophoblast, as opposed to choriocarcinoma, and is considered a benign tumour with expansion into the myometrium. Gestational trophoblastic disease as a total is considered a curable disease but the close cooperation of the Gynecologist, the Pathologist and the Oncologist is a prerequisite to that.

Key words: Gestational trophoblastic disease, choriocarci-noma, bcl-2.

BIBIOPAIA

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